Dataset Information

Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis.

ABSTRACT: Background:Although many studies have investigated the association of a single nucleotide polymorphism in TNF-? G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis. Method:Studies related to TNF-? G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homozygote comparison (GG vs AA), dominant (GG vs GA + AA), and recessive (GG + GA vs AA) to estimate the strength of the associations. Results:A total of 10 case-control studies were included in this meta-analysis. Overall, no significant association between TNF-? G-308A and depression was found (G vs A: OR [95% CI] =1.09 [0.92, 1.29]; GG vs AA: 1.24 [0.71, 2.15]; GG vs GA + AA: 1.01 [0.76, 1.35]; GG + GA vs AA: 1.22 [0.70, 2.13]). In subgroup analyses by ethnicity or age group, no statistically significant association between TNF-? G-308A polymorphisms and depression was shown. Conclusion:This meta-analysis revealed that TNF-? G-308A polymorphism is not associated with susceptibility to depression.

SUBMITTER: Shin KH

PROVIDER: S-EPMC5659227 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis.

Shin Kwang-Hee KH Jeong Hyeon Cheol HC Choi Dong-Hee DH Kim Sung Nyun SN Kim Tae-Eun TE

Neuropsychiatric disease and treatment 20171020

<h4>Background</h4>Although many studies have investigated the association of a single nucleotide polymorphism in TNF-α G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis.<h4>Method</h4>Studies related to TNF-α G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homo ...[more]

PMID: 29118582

Similar Datasets

Project description:Background Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained. Objective This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA. Methods Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren–Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue. Results A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62–1.15) in the recessive model] in the present case–control study, and analysis of other genetic models showed a similar trend. After adding the critical case–control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56–4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion. Conclusions The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required.

Dataset Information

Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis.

Publications

Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets