Ontology highlight
ABSTRACT:
SUBMITTER: Goldspink DA
PROVIDER: S-EPMC7342002 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Goldspink Deborah A DA Lu Van B VB Miedzybrodzka Emily L EL Smith Christopher A CA Foreman Rachel E RE Billing Lawrence J LJ Kay Richard G RG Reimann Frank F Gribble Fiona M FM
Cell reports 20200601 13
Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells are under development, with the aim to mimic endocrine effects of gastric bypass surgery, but they are difficult to develop without human L-cell models. Human ileal organoids, engineered by CRISPR-Cas9, express the fluorescent protein Venus in the proglu ...[more]