Ontology highlight
ABSTRACT:
SUBMITTER: Warner J
PROVIDER: S-EPMC7345757 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Warner Jeffrey J Hardesty Josiah J Zirnheld Kara K McClain Craig C Warner Dennis D Kirpich Irina I
Biology 20200612 6
Emerging evidence suggests that soluble epoxide hydrolase (sEH) inhibition is a valuable therapeutic strategy for the treatment of numerous diseases, including those of the liver. sEH rapidly degrades cytochrome P450-produced epoxygenated lipids (epoxy-fatty acids), which are synthesized from omega-3 and omega-6 polyunsaturated fatty acids, that generally exert beneficial effects on several cellular processes. sEH hydrolysis of epoxy-fatty acids produces dihydroxy-fatty acids which are typically ...[more]