Molecular mechanisms of sex bias differences in COVID-19 mortality.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7347256 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Molecular mechanisms of sex bias differences in COVID-19 mortality.
Li Yuchong Y Jerkic Mirjana M Slutsky Arthur S AS Zhang Haibo H
Critical care (London, England) 20200709 1
More men than women have died from COVID-19. Genes encoded on X chromosomes, and sex hormones may explain the decreased fatality of COVID-19 in women. The angiotensin-converting enzyme 2 gene is located on X chromosomes. Men, with a single X chromosome, may lack the alternative mechanism for cellular protection after exposure to SARS-CoV-2. Some Toll-like receptors encoded on the X chromosomes can sense SARS-CoV-2 nucleic acids, leading to a stronger innate immunity response in women. Both estro ...[more]
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