Dataset Information

The Clinical Application of EEG-Signals Recurrence Analysis as a Measure of Functional Connectivity: Comparative Case Study of Patients with Various Neuropsychiatric Disorders.

ABSTRACT: BACKGROUND:An electroencephalogram (EEG) is a simple and widely used assessment tool that allows one to analyze the bioelectric activity of the brain. As a result, one can observe brain waves with different frequencies and amplitudes that correspond to the temporary synchronization of different parts of the brain. Synchronization patterns may be changed by almost any type of pathological conditions, such as psychiatric diseases and structural abnormalities of the brain tissue. In various neuropsychiatric disorders, the coordination of cortical activity may be decreased or enhanced as a result of neurobiological compensatory mechanisms. METHODS:In this paper, we analyzed the EEG signals in resting-state condition, with reference to three patients with a similar set of psychopathological symptoms typical for the first psychotic episode, but with different functional and structural neural basis of the disease. Additionally, those patients were compared with a demographically matched healthy individual. We used the non-linear method of time series analysis based on the recurrences of states, to verify whether functional connectivity configurations assessed with recurrence method will qualitatively distinguish patients from a healthy subject, but also differentiate patients from each other. RESULTS:Obtained results confirmed that the connectivity architecture mapped with the recurrence analysis substantially differentiated all participants from each other. An applied analysis additionally showed the specificity of cortical desynchronization and over-synchronization matched to the psychiatric or neurological basis of the disease. Despite this encouraging finding, group-oriented studies are needed to corroborate our qualitative results, based only on a series of clinical case studies.

SUBMITTER: Jonak K

PROVIDER: S-EPMC7349203 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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The Clinical Application of EEG-Signals Recurrence Analysis as a Measure of Functional Connectivity: Comparative Case Study of Patients with Various Neuropsychiatric Disorders.

Jonak Kamil K Syta Arkadiusz A Karakuła-Juchnowicz Hanna H Krukow Paweł P

Brain sciences 20200616 6

<h4>Background</h4>An electroencephalogram (EEG) is a simple and widely used assessment tool that allows one to analyze the bioelectric activity of the brain. As a result, one can observe brain waves with different frequencies and amplitudes that correspond to the temporary synchronization of different parts of the brain. Synchronization patterns may be changed by almost any type of pathological conditions, such as psychiatric diseases and structural abnormalities of the brain tissue. In various ...[more]

PMID: 32560205

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Project description:Motivation. Anomaly EEG detection is a long-standing problem in analysis of EEG signals. The basic premise of this problem is consideration of the similarity between two nonstationary EEG recordings. A well-established scheme is based on sequence matching, typically including three steps: feature extraction, similarity measure, and decision-making. Current approaches mainly focus on EEG feature extraction and decision-making, and few of them involve the similarity measure/quantification. Generally, to design an appropriate similarity metric, that is compatible with the considered problem/data, is also an important issue in the design of such detection systems. It is however impossible to directly apply those existing metrics to anomaly EEG detection without any consideration of domain specificity. Methodology. The main objective of this work is to investigate the impacts of different similarity metrics on anomaly EEG detection. A few metrics that are potentially available for the EEG analysis have been collected from other areas by a careful review of related works. The so-called power spectrum is extracted as features of EEG signals, and a null hypothesis testing is employed to make the final decision. Two indicators have been used to evaluate the detection performance. One is to reflect the level of measured similarity between two compared EEG signals, and the other is to quantify the detection accuracy. Results. Experiments were conducted on two data sets, respectively. The results demonstrate the positive impacts of different similarity metrics on anomaly EEG detection. The Hellinger distance (HD) and Bhattacharyya distance (BD) metrics show excellent performances: an accuracy of 0.9167 for our data set and an accuracy of 0.9667 for the Bern-Barcelona EEG data set. Both of HD and BD metrics are constructed based on the Bhattacharyya coefficient, implying the priority of the Bhattacharyya coefficient when dealing with the highly noisy EEG signals. In future work, we will exploit an integrated metric that combines HD and BD for the similarity measure of EEG signals.

Dataset Information

The Clinical Application of EEG-Signals Recurrence Analysis as a Measure of Functional Connectivity: Comparative Case Study of Patients with Various Neuropsychiatric Disorders.

Publications

The Clinical Application of EEG-Signals Recurrence Analysis as a Measure of Functional Connectivity: Comparative Case Study of Patients with Various Neuropsychiatric Disorders.

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