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SNAP-25 in neuropsychiatric disorders.

ABSTRACT: SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

SUBMITTER: Corradini I

PROVIDER: S-EPMC2706123 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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SNAP-25 in neuropsychiatric disorders.

Corradini Irene I Verderio Claudia C Sala Mariaelvina M Wilson Michael C MC Matteoli Michela M

Annals of the New York Academy of Sciences 20090101

SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic stu ...[more]

PMID: 19161380

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