Ontology highlight
ABSTRACT:
SUBMITTER: Corradini I
PROVIDER: S-EPMC2706123 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Corradini Irene I Verderio Claudia C Sala Mariaelvina M Wilson Michael C MC Matteoli Michela M
Annals of the New York Academy of Sciences 20090101
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic stu ...[more]