MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI.
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ABSTRACT:
SUBMITTER: Hong J
PROVIDER: S-EPMC7349421 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI.
Hong Jun J Hu Bang-Chuan BC Xu Liang L Zheng Yang Y Shao Zi-Qiang ZQ Zhang Run R Yang Xiang-Hong XH Sun Ren-Hua RH Mo Shi-Jing SJ
Analytical cellular pathology (Amsterdam) 20200701
Fibroblast growth factor-inducible molecule 14 (Fn14) plays a principal role in triggering tubular damage during septic acute kidney injury (AKI). Here, we explore the mechanism underlying Fn14 deregulation in septic AKI. We identify Fn14 as a bona fide target of miR-19a, which directly binds to 3' UTR of Fn14 for repression independent of cylindromatosis (CYLD), the deubiquitinase (DUB) downstream of miR-19a, and thereby antagonizes the LPS-induced tubular cell apoptosis. Genetic ablation of Fn ...[more]
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