Ontology highlight
ABSTRACT:
SUBMITTER: Ganesh K
PROVIDER: S-EPMC7351134 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ganesh Karuna K Basnet Harihar H Kaygusuz Yasemin Y Laughney Ashley M AM He Lan L Sharma Roshan R O'Rourke Kevin P KP Reuter Vincent P VP Huang Yun-Han YH Turkekul Mesruh M Er Ekrem Emrah EE Masilionis Ignas I Manova-Todorova Katia K Weiser Martin R MR Saltz Leonard B LB Garcia-Aguilar Julio J Koche Richard R Lowe Scott W SW Pe'er Dana D Shia Jinru J Massagué Joan J
Nature cancer 20200113 1
Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and relationship to primary-tumor-initiating stem cells are not known. We show that L1CAM<sup>+</sup> cells in human colorectal cancer (CRC) have metastasis-initiating capacity, and we define their relationship to tissue regeneration. L1CAM is not expressed in the homeostatic intestinal epithelium, but is induced and required for epithelial regeneration following colitis and in CRC organoid growth. By ...[more]