Ontology highlight
ABSTRACT:
SUBMITTER: Dosset M
PROVIDER: S-EPMC7352225 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Dosset Magalie M Castro Andrea A Carter Hannah H Zanetti Maurizio M
Cancers 20200625 6
Telomerase reverse transcriptase (TERT) is a conserved self-tumor antigen which is overexpressed in most tumors and plays a critical role in tumor formation and progression. As such, TERT is an antigen of great relevance to develop widely applicable immunotherapies. CD4 T cells play a major role in the anti-cancer response alone or with other effector cells such as CD8 T cells and NK cells. To date, efforts have been made to identify TERT peptides capable of stimulating CD4 T cells that are also ...[more]