Ontology highlight
ABSTRACT:
SUBMITTER: Brinton LT
PROVIDER: S-EPMC7352446 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Brinton Lindsey T LT Sher Steven S Williams Katie K Canfield Daniel D Orwick Shelley S Wasmuth Ronni R Cempre Casey C Skinner Jordan J Lehman Amy A Blachly James S JS Byrd John C JC Lapalombella Rosa R
Cancers 20200614 6
Acute myeloid leukemia (AML) is a hematopoietic stem-cell-derived leukemia with often successive derived driver mutations. Late onset acquisition of internal tandem duplication in <i>FLT3</i> (<i>FLT3</i>-ITD) at a high variant allele frequency often contributes to full transformation to a highly proliferative, rapidly progressive disease with poor outcome. The <i>FLT3</i>-ITD mutation is targetable with approved FLT3 small molecule inhibitors, including midostaurin and gilteritinib. However, ou ...[more]