Ontology highlight
ABSTRACT:
SUBMITTER: Meunier G
PROVIDER: S-EPMC7581748 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Meunier Godelieve G Birsen Rudy R Cazelles Clarisse C Belhadj Maya M Cantero-Aguilar Lilia L Kosmider Olivier O Fontenay Michaela M Azar Nabih N Mayeux Patrick P Chapuis Nicolas N Tamburini Jerôme J Bouscary Didier D
Oncogenesis 20201022 10
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis. Vacuolar protein sorting 34 (VPS34) is a member of the phosphatidylinositol-3-kinase lipid kinase family that controls the canonical autophagy pathway and vesicular trafficking. Using a recently developed specific inhibitor (VPS34-IN1), we found that VPS34 inhibition induces apoptosis in AML cells but not in normal CD34+ hematopoietic cells. Complete and acute inhibition of VPS34 was required for the antileukemic activi ...[more]