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Investigating the Role of PPAR?/? in Retinal Vascular Remodeling Using Ppar?/?-Deficient Mice.

ABSTRACT: Peroxisome proliferator-activated receptor (PPAR)?/? is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Ppar?/?-deficient mice. However, PPAR?/?'s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPAR?/? is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Ppar?/?-haplodeficient mice. In summary, these results indicated a critical role of PPAR?/? in pathological angiogenesis and blood vessel remodeling in the retina.

SUBMITTER: Ho SY 

PROVIDER: S-EPMC7353058 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice.

Ho Sze Yuan SY   Kwan Yuet Ping YP   Qiu Beiying B   Tan Alison A   Murray Hannah Louise HL   Barathi Veluchamy Amutha VA   Tan Nguan Soon NS   Cheung Chui Ming Gemmy CMG   Wong Tien Yin TY   Wahli Walter W   Wang Xiaomeng X  

International journal of molecular sciences 20200620 12

Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in <i>Pparβ</i>/<i>δ</i>-deficient mice. However, PPARβ/δ's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our s  ...[more]

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