Ontology highlight
ABSTRACT:
SUBMITTER: Iglesias J
PROVIDER: S-EPMC3484427 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Iglesias José J Barg Sebastian S Vallois David D Lahiri Shawon S Roger Catherine C Yessoufou Akadiri A Pradevand Sylvain S McDonald Angela A Bonal Claire C Reimann Frank F Gribble Fiona F Debril Marie-Bernard MB Metzger Daniel D Chambon Pierre P Herrera Pedro P Rutter Guy A GA Prentki Marc M Thorens Bernard B Wahli Walter W
The Journal of clinical investigation 20121024 11
PPARβ/δ protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined. To gain insight into its hypothesized role in β cell function, we specifically deleted Pparb/d in the epithelial compartment of the mouse pancreas. Mutant animals presented increased numbers of islets and, more importantly, enhanced insulin secretion, causing hyperinsulinemia. Gene expression profiling of pancrea ...[more]