Ontology highlight
ABSTRACT:
SUBMITTER: Kon E
PROVIDER: S-EPMC7355647 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kon Edo E Hazan-Halevy Inbal I Rosenblum Daniel D Cohen Niv N Chatterjee Sushmita S Veiga Nuphar N Raanani Pia P Bairey Osnat O Benjamini Ohad O Nagler Arnon A Peer Dan D
Pharmaceutics 20200607 6
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western populations. Therapies such as mRNA and siRNA encapsulated in lipid nanoparticles (LNPs) represent a clinically advanced platform and are utilized for a wide variety of applications. Unfortunately, transfection of RNA into CLL cells remains a formidable challenge and a bottleneck for developing targeted therapies for this disease. Therefore, we aimed to elucidate the barriers to efficient transfection of RNA-encapsul ...[more]