Ontology highlight
ABSTRACT:
SUBMITTER: Sakurai Y
PROVIDER: S-EPMC9413996 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Sakurai Yu Y Watanabe Himeka H Nishio Kazuma K Hashimoto Kohei K Harada Atsuki A Gomi Masaki M Suzuki Masayoshi M Oyama Ryotaro R Handa Takumi T Sato Risa R Takeuchi Hina H Taira Ryoga R Tezuka Kenta K Tange Kota K Nakai Yuta Y Akita Hidetaka H Uchida Yasuo Y
Pharmaceutics 20220727 8
The blood-brain barrier (BBB), which is comprised of brain capillary endothelial cells, plays a pivotal role in the transport of drugs from the blood to the brain. Therefore, an analysis of proteins in the endothelial cells, such as transporters and tight junction proteins, which contribute to BBB function, is important for the development of therapeutics for the treatment of brain diseases. However, gene transfection into the vascular endothelial cells of the BBB is fraught with difficulties, e ...[more]