Ontology highlight
ABSTRACT:
SUBMITTER: Terradas M
PROVIDER: S-EPMC7355797 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Journal of clinical medicine 20200623 6
In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in hereditary CRC and/or colorectal carcinogenesis. To date, only pathogenic variants in <i>RPS20</i> may be convincedly linked to hereditary CRC. Nevertheless, accumulated evidence supports t ...[more]