Ontology highlight
ABSTRACT:
SUBMITTER: Freitas Leal JK
PROVIDER: S-EPMC7356037 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Freitas Leal Joames K JK Lasonder Edwin E Sharma Vikram V Schiller Jürgen J Fanelli Giuseppina G Rinalducci Sara S Brock Roland R Bosman Giel G
Proteomes 20200331 2
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions. The triggers and mechanisms of microvesicle generation are largely unknown. In this study, we combined morphological, immunochemical, proteomic, lipidomic, and metabolomic analyses to obtain an integrated understanding of the mechanisms underlying ...[more]