Ontology highlight
ABSTRACT:
SUBMITTER: Passos DO
PROVIDER: S-EPMC7357238 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Passos Dario Oliveira DO Li Min M Jóźwik Ilona K IK Zhao Xue Zhi XZ Santos-Martins Diogo D Yang Renbin R Smith Steven J SJ Jeon Youngmin Y Forli Stefano S Hughes Stephen H SH Burke Terrence R TR Craigie Robert R Lyumkis Dmitry D
Science (New York, N.Y.) 20200130 6479
The HIV intasome is a large nucleoprotein assembly that mediates the integration of a DNA copy of the viral genome into host chromatin. Intasomes are targeted by the latest generation of antiretroviral drugs, integrase strand-transfer inhibitors (INSTIs). Challenges associated with lentiviral intasome biochemistry have hindered high-resolution structural studies of how INSTIs bind to their native drug target. Here, we present high-resolution cryo-electron microscopy structures of HIV intasomes b ...[more]