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ENERGY SENSING PATHWAYS IN AGING AND CHRONIC LUNG DISEASE.

ABSTRACT: Aging is associated with an increased risk of a number of clinical syndromes, including chronic lung disease. There have been significant advances in our understanding of the biology of aging leading to the elucidation of the so-called "hallmarks of aging." The cause-effect relationships between various hallmarks such as dysregulated nutrient sensing, mitochondrial dysfunction, and cellular senescence are not well understood. Here, I discuss the evidence for alterations in energy/metabolic sensing pathways in the degenerative chronic lung disease called idiopathic pulmonary fibrosis (IPF). The pathobiological mechanisms by which this defect may contribute to age-related susceptibility to IPF and potentially other diseases of the elderly are also discussed.

SUBMITTER: Thannickal VJ

PROVIDER: S-EPMC7358504 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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ENERGY SENSING PATHWAYS IN AGING AND CHRONIC LUNG DISEASE.

Thannickal Victor J VJ

Transactions of the American Clinical and Climatological Association 20200101

Aging is associated with an increased risk of a number of clinical syndromes, including chronic lung disease. There have been significant advances in our understanding of the biology of aging leading to the elucidation of the so-called "hallmarks of aging." The cause-effect relationships between various hallmarks such as dysregulated nutrient sensing, mitochondrial dysfunction, and cellular senescence are not well understood. Here, I discuss the evidence for alterations in energy/metabolic sensi ...[more]

PMID: 32675866

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