Ontology highlight
ABSTRACT:
SUBMITTER: Longo J
PROVIDER: S-EPMC7359767 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Longo Joseph J Smirnov Petr P Li Zhihua Z Branchard Emily E van Leeuwen Jenna E JE Licht Jonathan D JD Haibe-Kains Benjamin B Andrews David W DW Keats Jonathan J JJ Pugh Trevor J TJ Trudel Suzanne S Penn Linda Z LZ
Leukemia 20200714 3
Multiple myeloma (MM) is a plasma cell malignancy that is often driven by chromosomal translocations. In particular, patients with t(4;14)-positive disease have worse prognosis compared to other MM subtypes. Herein, we demonstrated that t(4;14)-positive cells are highly dependent on the mevalonate (MVA) pathway for survival. Moreover, we showed that this metabolic vulnerability is immediately actionable, as inhibiting the MVA pathway with a statin preferentially induced apoptosis in t(4;14)-posi ...[more]