Ontology highlight
ABSTRACT:
SUBMITTER: Qing J
PROVIDER: S-EPMC2673861 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Qing Jing J Du Xiangnan X Chen Yongmei Y Chan Pamela P Li Hao H Wu Ping P Marsters Scot S Stawicki Scott S Tien Janet J Totpal Klara K Ross Sarajane S Stinson Susanna S Dornan David D French Dorothy D Wang Qian-Rena QR Stephan Jean-Philippe JP Wu Yan Y Wiesmann Christian C Ashkenazi Avi A
The Journal of clinical investigation 20090420 5
Overexpression of FGF receptor 3 (FGFR3) is implicated in the development of t(4;14)-positive multiple myeloma. While FGFR3 is frequently overexpressed and/or activated through mutations in bladder cancer, the functional importance of FGFR3 and its potential as a specific therapeutic target in this disease have not been elucidated in vivo. Here we report that inducible knockdown of FGFR3 in human bladder carcinoma cells arrested cell-cycle progression in culture and markedly attenuated tumor pro ...[more]