Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC7359949 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zhang Lingxin L Sarangi Vivekananda V Moon Irene I Yu Jia J Liu Duan D Devarajan Sandhya S Reid Joel M JM Kalari Krishna R KR Wang Liewei L Weinshilboum Richard R
Clinical and translational science 20200310 4
Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge for pharmacogenomics. Deep mutational scanning (DMS) is a high-throughput technique that makes it possible to analyze the functional effect of hundreds of variants in a parallel and scalable fashion. We adapted a "landing pad" DMS system to study ...[more]