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Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

ABSTRACT: Invasive lobular carcinoma comprises 10-15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma include E-cadherin loss, leading to discohesive morphology with cells proliferating in single-file strands and oestrogen receptor positivity, with favourable response to endocrine therapy. This review summarises the distinct histological and molecular features of invasive lobular carcinoma with focus on diagnostic challenges and the impact on surgical management and medical therapy. Emphasis is placed on recent advances in our understanding of the unique molecular biology of lobular breast cancer and how this is optimising our therapy approach in the clinic.

SUBMITTER: Luveta J

PROVIDER: S-EPMC7359988 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

Luveta Jocelyn J Parks Ruth M RM Heery David M DM Cheung Kwok-Leung KL Johnston Simon J SJ

Oncology and therapy 20191224 1

Invasive lobular carcinoma comprises 10-15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma include E-cadherin loss, leading to discohesive morphology with cells proliferating in single-file strands and oestrogen receptor positivity, with favourable response to endocrine therapy. This review summarises the distinct histological and mol ...[more]

PMID: 32700069

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Immune Infiltration in Invasive Lobular Breast Cancer.

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| S-EPMC6037125 | biostudies-literature

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.

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Tamoxifen response and resistance in invasive lobular breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-03-16 | GSE96670 | GEO

ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer.

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| S-EPMC2701641 | biostudies-literature

Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells.

Project description:Invasive lobular breast carcinoma (ILC), one of the major breast cancer histologic subtypes, exhibits unique features compared with the well-studied ductal cancer subtype (IDC). The pathognomonic feature of ILC is loss of E-cadherin, mainly caused by inactivating mutations, but the contribution of this genetic alteration to ILC-specific molecular characteristics remains largely understudied. To profile these features transcriptionally, we conducted single-cell RNA sequencing on a panel of IDC and ILC cell lines, and an IDC cell line (T47D) with CRISPR-Cas9-mediated E-cadherin knockout (KO). Inspection of intracell line heterogeneity illustrated genetically and transcriptionally distinct subpopulations in multiple cell lines and highlighted rare populations of MCF7 cells highly expressing an apoptosis-related signature, positively correlated with a preadaptation signature to estrogen deprivation. Investigation of E-cadherin KO-induced alterations showed transcriptomic membranous systems remodeling, elevated resemblance to ILCs in regulon activation, and increased sensitivity to IFNγ-mediated growth inhibition via activation of IRF1. This study reveals single-cell transcriptional heterogeneity in breast cancer cell lines and provides a resource to identify drivers of cancer progression and drug resistance. SIGNIFICANCE: This study represents a key step towards understanding heterogeneity in cancer cell lines and the role of E-cadherin depletion in contributing to the molecular features of invasive lobular breast carcinoma.

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Reporting on invasive lobular breast cancer in clinical trials: a systematic review.

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| S-EPMC10954721 | biostudies-literature

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