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Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.


ABSTRACT: Invasive lobular carcinoma comprises 10-15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma include E-cadherin loss, leading to discohesive morphology with cells proliferating in single-file strands and oestrogen receptor positivity, with favourable response to endocrine therapy. This review summarises the distinct histological and molecular features of invasive lobular carcinoma with focus on diagnostic challenges and the impact on surgical management and medical therapy. Emphasis is placed on recent advances in our understanding of the unique molecular biology of lobular breast cancer and how this is optimising our therapy approach in the clinic.

SUBMITTER: Luveta J 

PROVIDER: S-EPMC7359988 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

Luveta Jocelyn J   Parks Ruth M RM   Heery David M DM   Cheung Kwok-Leung KL   Johnston Simon J SJ  

Oncology and therapy 20191224 1


Invasive lobular carcinoma comprises 10-15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma include E-cadherin loss, leading to discohesive morphology with cells proliferating in single-file strands and oestrogen receptor positivity, with favourable response to endocrine therapy. This review summarises the distinct histological and mol  ...[more]

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