Ontology highlight
ABSTRACT:
SUBMITTER: Licht-Mayer S
PROVIDER: S-EPMC7360646 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Licht-Mayer Simon S Campbell Graham R GR Canizares Marco M Mehta Arpan R AR Gane Angus B AB McGill Katie K Ghosh Aniket A Fullerton Alexander A Menezes Niels N Dean Jasmine J Dunham Jordon J Al-Azki Sarah S Pryce Gareth G Zandee Stephanie S Zhao Chao C Kipp Markus M Smith Kenneth J KJ Baker David D Altmann Daniel D Anderton Stephen M SM Kap Yolanda S YS Laman Jon D JD Hart Bert A 't BA' Rodriguez Moses M Watzlawick Ralf R Schwab Jan M JM Carter Roderick R Morton Nicholas N Zagnoni Michele M Franklin Robin J M RJM Mitchell Rory R Fleetwood-Walker Sue S Lyons David A DA Chandran Siddharthan S Lassmann Hans H Trapp Bruce D BD Mahad Don J DJ
Acta neuropathologica 20200622 2
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood. The abundance of mitochondria in demyelinated axons in MS raises the possibility that increased mitochondrial content serves as a compensatory response to demyelination. Here, we show that upon demyelination mitochondria move from the neuronal cell body to the demyel ...[more]