Ontology highlight
ABSTRACT:
SUBMITTER: Chong WP
PROVIDER: S-EPMC7362799 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chong Wai Po WP Mattapallil Mary J MJ Raychaudhuri Kumarkrishna K Bing So Jin SJ Wu Sihan S Zhong Yajie Y Wang WeiWei W Chen Zilin Z Silver Phyllis B PB Jittayasothorn Yingyos Y Chan Chi-Chao CC Chen Jun J Horai Reiko R Caspi Rachel R RR
Immunity 20200715 2
Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials targeting IL-17A in uveitis were not successful. Here, we report that Th17 cells were regulated by their own signature cytokine, IL-17A. Loss of IL-17A in autopathogenic Th17 cells did not reduce their pathogenicity and instead elevated their expression of the Th17 cytokines GM-CSF and IL-17F. Mechanistic in vitro studies reveal ...[more]