UV-responsive cyclic peptide progelator bioinks.
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ABSTRACT:
SUBMITTER: Carlini AS
PROVIDER: S-EPMC7363176 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
UV-responsive cyclic peptide progelator bioinks.
Carlini Andrea S AS Touve Mollie A MA Fernández-Caro Héctor H Thompson Matthew P MP Cassidy Mary F MF Cao Wei W Gianneschi Nathan C NC
Faraday discussions 20191001 0
We describe cyclic peptide progelators which cleave in response to UV light to generate linearized peptides which then self-assemble into gel networks. Cyclic peptide progelators were synthesized, where the peptides were sterically constrained, but upon UV irradiation, predictable cleavage products were generated. Amino acid sequences and formulation conditions were altered to tune the mechanical properties of the resulting gels. Characterization of the resulting morphologies and chemistry was a ...[more]
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