Ontology highlight
ABSTRACT:
SUBMITTER: Thuy LTT
PROVIDER: S-EPMC7364355 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Thuy Le Thi Thanh LTT Hai Hoang H Kawada Norifumi N
Clinical and molecular hepatology 20200604 3
Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish stellate cells from hepatic fibroblast-derived myofibroblasts. Loss of Cygb accelerates liver fibrosis and cancer development in mouse models of chronic liver injury including diethylnitrosamine-induced hepatocellular carcinoma, bile duct ligati ...[more]