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Regio- and Stereoselective Synthesis of 1,2-Dihaloalkenes Using In-Situ-Generated ICl, IBr, BrCl, I2, and Br2.

ABSTRACT: We describe a catalyst-free 1,2-trans-dihalogenation of alkynes with an unprecedented substrate scope and exclusive regio- and stereoselectivity. This versatile dihalogenation system-a combination of NX¹S electrophile and alkali metal halide (MX²) in acetic acid-is applicable for diverse categories of alkynes (electron-rich or poor alkynes, internal and terminal alkynes, or heteroatoms such as O-, N-, S-substituted alkynes). The hydrogen bonding donor solvent acetic acid is essential for the in-situ generation of X¹X² electrophile, including ICl, IBr, BrCl, I_2, and Br₂.

SUBMITTER: Zeng X

PROVIDER: S-EPMC7367077 | biostudies-literature |

REPOSITORIES: biostudies-literature

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