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Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease.

ABSTRACT: In this issue of Clinical Kidney Journal, Gamayo et al. describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of the present report consists of the association of a disease thought to be rare (only 13 in prior described patients, 11 in the past year) with B-cell lymphoproliferative disease. Together with the finding of a third case among 224 elderly patients studied, this raises the issue of the underdiagnoses of LRP2 nephropathy, on top of the potential association to B-cell malignancy. We now put these findings in context within the wider frame of autoimmunity against megalin/LRP2 and related antigens such as Fx1A and CD69.

SUBMITTER: Perez-Gomez MV

PROVIDER: S-EPMC7367110 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease.

Perez-Gomez Maria V MV Sanchez-Niño Maria D MD Ortiz Alberto A

Clinical kidney journal 20200319 3

In this issue of <i>Clinical Kidney Journal</i>, Gamayo <i>et al.</i> describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of the present report consists of the association of a disease thought to be rare (only 13 in prior described patients, 11 in the past year) with B-cell lymphoproliferative disease. Togethe ...[more]

PMID: 32701075

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