Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7367283 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Liu Yongfeng Y Xu Xianjin X Gao Junyuan J Naffaa Moawiah M MM Liang Hongwu H Shi Jingyi J Wang Hong Zhan HZ Yang Nien-Du ND Hou Panpan P Zhao Wenshan W White Kelli McFarland KM Kong Wenjuan W Dou Alex A Cui Amy A Zhang Guohui G Cohen Ira S IS Zou Xiaoqin X Cui Jianmin J
Communications biology 20200716 1
KCNQ family K<sup>+</sup> channels (KCNQ1-5) in the heart, nerve, epithelium and ear require phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) for voltage dependent activation. While membrane lipids are known to regulate voltage sensor domain (VSD) activation and pore opening in voltage dependent gating, PIP<sub>2</sub> was found to interact with KCNQ1 and mediate VSD-pore coupling. Here, we show that a compound CP1, identified in silico based on the structures of both KCNQ1 and PIP<sub>2< ...[more]