Ontology highlight
ABSTRACT:
SUBMITTER: Conti L
PROVIDER: S-EPMC4899724 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Conti Luca L Renhorn Jakob J Gabrielsson Anders A Turesson Fredrik F Liin Sara I SI Lindahl Erik E Elinder Fredrik F
Scientific reports 20160609
Voltage-gated potassium channels open at depolarized membrane voltages. A prolonged depolarization causes a rearrangement of the selectivity filter which terminates the conduction of ions - a process called slow or C-type inactivation. How structural rearrangements in the voltage-sensor domain (VSD) cause alteration in the selectivity filter, and vice versa, are not fully understood. We show that pulling the pore domain of the Shaker potassium channel towards the VSD by a Cd(2+) bridge accelerat ...[more]