Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation.

ABSTRACT: Long distance tangential migration transports neurons from their birth places to distant destinations to be incorporated into neuronal circuits. How neuronal migration is guided during these long journeys is still not fully understood. We address this issue by studying the migration of pontine nucleus (PN) neurons in the mouse hindbrain. PN neurons migrate from the lower rhombic lip first anteriorly and then turn ventrally near the trigeminal ganglion root towards the anterior ventral hindbrain. Previously we showed that in mouse depleted of chemokine receptor CXCR4 or its ligand CXCL12, PN neurons make their anterior-to-ventral turn at posteriorized positions. However, the mechanism that spatiotemporally controls the anterior-to-ventral turning is still unclear. Furthermore, the role of C

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7367352 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature