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Cognitive Impairment Is Associated with Absolute Intraoperative Frontal ?-Band Power but Not with Baseline ?-Band Power: A Pilot Study.

ABSTRACT: BACKGROUND:Cognitive abilities decline with aging, leading to a higher risk for the development of postoperative delirium or postoperative neurocognitive disorders after general anesthesia. Since frontal ?-band power is known to be highly correlated with cognitive function in general, we hypothesized that preoperative cognitive impairment is associated with lower baseline and intraoperative frontal ?-band power in older adults. METHODS:Patients aged ?65 years undergoing elective surgery were included in this prospective observational study. Cognitive function was assessed on the day before surgery using six age-sensitive cognitive tests. Scores on those tests were entered into a principal component analysis to calculate a composite "g score" of global cognitive ability. Patient groups were dichotomized into a lower cognitive group (LC) reaching the lower 1/3 of "g scores" and a normal cognitive group (NC) consisting of the upper 2/3 of "g scores." Continuous pre- and intraoperative frontal electroencephalograms (EEGs) were recorded. EEG spectra were analyzed at baseline, before start of anesthesia medication, and during a stable intraoperative period. Significant differences in band power between the NC and LC groups were computed by using a frequency domain (? 0.5-3 Hz, ? 4-7 Hz, ? 8-12 Hz, ? 13-30 Hz)-based bootstrapping algorithm. RESULTS:Of 38 included patients (mean age 72 years), 24 patients were in the NC group, and 14 patients had lower cognitive abilities (LC). Intraoperative ?-band power was significantly reduced in the LC group compared to the NC group (NC -1.6 [-4.48/1.17] dB vs. LC -6.0 [-9.02/-2.64] dB), and intraoperative ?-band power was positively correlated with "g score" (Spearman correlation: r = 0.381; p = 0.018). Baseline EEG power did not show any associations with "g." CONCLUSIONS:Preoperative cognitive impairment in older adults is associated with intraoperative absolute frontal ?-band power, but not baseline ?-band power.

SUBMITTER: Koch S

PROVIDER: S-EPMC7367434 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study.

Koch Susanne S Feinkohl Insa I Chakravarty Sourish S Windmann Victoria V Lichtner Gregor G Pischon Tobias T Brown Emery N EN Spies Claudia C

Dementia and geriatric cognitive disorders 20191002 1-2

<h4>Background</h4>Cognitive abilities decline with aging, leading to a higher risk for the development of postoperative delirium or postoperative neurocognitive disorders after general anesthesia. Since frontal α-band power is known to be highly correlated with cognitive function in general, we hypothesized that preoperative cognitive impairment is associated with lower baseline and intraoperative frontal α-band power in older adults.<h4>Methods</h4>Patients aged ≥65 years undergoing elective s ...[more]

PMID: 31578031

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Dataset Information

Cognitive Impairment Is Associated with Absolute Intraoperative Frontal ?-Band Power but Not with Baseline ?-Band Power: A Pilot Study.

Publications

Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study.

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