Ontology highlight
ABSTRACT:
SUBMITTER: Cao J
PROVIDER: S-EPMC7367451 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cao Jianlei J Da Yurong Y Li Hang H Peng Yuanyuan Y Hu Xiaorong X
PloS one 20200717 7
Both MicroRNAs and HMGB1 took part in pathological process of myocardial I/R injury though several signaling pathways. We hypothesized that mircoRNA451 (miR-451), a group of small non-coding RNAs, could improve this injury by inhibiting HMGB1. Male SD rats were randomly distributed into 5 groups and subjected to I/R process. After 24 hours of reperfusion injury, the serum content of CK and LDH, the content of MDA in tissue and activity of SOD were detected; The infarcted areas were defined by TT ...[more]