Ontology highlight
ABSTRACT:
SUBMITTER: Xiong J
PROVIDER: S-EPMC5746084 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Xiong Junjie J Wang Dan D Wei Ailin A Ke Nengwen N Wang Yichao Y Tang Jie J He Sirong S Hu Weiming W Liu Xubao X
Oncotarget 20171118 64
Gemcitabine-based chemotherapy is the most common treatment option for pancreatic ductal adenocarcinoma (PDAC). However, it offers little therapeutic value in many cases due to the rapid development of chemoresistance. MicroRNAs (miRNAs) have been found to play pivotal roles in the chemotherapeutic resistance of PDAC. We found that miR-410-3p was significantly down-regulated in human pancreatic cancer xenograft (HPCx) tumor tissues from gemcitabine-treated mice. Low miR-410-3p expression correla ...[more]