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Clinical Management of Locally Advanced Basal-Cell Carcinomas and Future Therapeutic Directions.

ABSTRACT: Treatment of choice for nodular basal-cell carcinomas (BCCs) is complete excision, implying that small lesions are of minor concern. Metastasis is very rare (

SUBMITTER: Niebel D 

PROVIDER: S-EPMC7367955 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Clinical Management of Locally Advanced Basal-Cell Carcinomas and Future Therapeutic Directions.

Niebel Dennis D   Sirokay Judith J   Hoffmann Friederike F   Fröhlich Anne A   Bieber Thomas T   Landsberg Jennifer J  

Dermatology and therapy 20200507 4

Treatment of choice for nodular basal-cell carcinomas (BCCs) is complete excision, implying that small lesions are of minor concern. Metastasis is very rare (< 1%). However, locally advanced basal-cell carcinomas (laBCCs), which are ineligible for surgery or radiation, are a therapeutic challenge. First-generation Smoothened (SMO) inhibitors (vismodegib, sonidegib) have been approved for treatment, but common side effects limit their use. Numerous new compounds are being investigated in clinical  ...[more]

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