Ontology highlight
ABSTRACT:
SUBMITTER: Greenshields-Watson A
PROVIDER: S-EPMC7370177 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Greenshields-Watson Alexander A Attaf Meriem M MacLachlan Bruce J BJ Whalley Thomas T Rius Cristina C Wall Aaron A Lloyd Angharad A Hughes Hywel H Strange Kathryn E KE Mason Georgina H GH Schauenburg Andrea J AJ Hulin-Curtis Sarah L SL Geary James J Chen Yuan Y Lauder Sarah N SN Smart Kathryn K Vijaykrishna Dhanasekaran D Grau Miguel L ML Shugay Mikhail M Andrews Robert R Dolton Garry G Rizkallah Pierre J PJ Gallimore Awen M AM Sewell Andrew K AK Godkin Andrew J AJ Cole David K DK
Cell reports 20200701 2
T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8<sup>+</sup> T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4<sup>+</sup> T c ...[more]