Ontology highlight
ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC7371431 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Chen Qian Q Rehman Jalees J Chan Manwai M Fu Panfeng P Dudek Steven M SM Natarajan Viswanathan V Malik Asrar B AB Liu Yuru Y
Cell reports 20200601 13
Lung alveolar epithelium is composed of alveolar type I (AT1) and type II (AT2) cells. AT1 cells mediate gas exchange, whereas AT2 cells act as progenitor cells to repair injured alveoli. Lung microvascular endothelial cells (LMVECs) play a crucial but still poorly understood role in regulating alveolar repair. Here, we studied the role of the LMVEC-derived bioactive lipid sphingosine-1-phosphate (S1P) in promoting alveolar repair using mice with endothelial-specific deletion of sphingosine kina ...[more]