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Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results.


ABSTRACT: PURPOSE:The COVID-19 outbreak is affecting people worldwide. Many infected patients have respiratory involvement that may progress to acute respiratory distress syndrome. This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiation therapy in patients with COVID-19 pneumonia. METHODS AND MATERIALS:In this clinical trial, conducted in Iran, we enrolled patients with COVID-19 who were older than 60 years and hospitalized to receive supplementary oxygen for their documented pneumonia. Participants were treated with whole-lung irradiation in a single fraction of 0.5 Gy plus the national protocol for the management of COVID-19. Vital signs (including blood oxygenation and body temperature) and laboratory findings (interleukin-6 and C-reactive peptide) were recorded before and after irradiation. RESULTS:Between May 21, 2020 and June 24, 2020, 5 patients received whole-lung irradiation. They were followed for 5 to 7 days to evaluate the response to treatment and toxicities. The clinical and paraclinical findings of 4 of the 5 patients (patient 4 worsened and died on day 3) improved on the first day of irradiation. Patient 3 opted out of the trial on the third day after irradiation. The mean time to discharge was 6 days for the other 3 patients. No acute radiation-induced toxicity was recorded. CONCLUSIONS:With a response rate of 80%, whole-lung irradiation in a single fraction of 0.5 Gy had encouraging results in oxygen-dependent patients with COVID-19 pneumonia.

SUBMITTER: Ameri A 

PROVIDER: S-EPMC7373065 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results.

Ameri Ahmad A   Rahnama Nazanin N   Bozorgmehr Rama R   Mokhtari Majid M   Farahbakhsh Mohammad M   Nabavi Mahmood M   Shoaei Simin Dokht SD   Izadi Hossein H   Yousefi Kashi Amir Shahram AS   Dehbaneh Hadiseh Shabanpour HS   Taghizadeh-Hesary Farzad F  

International journal of radiation oncology, biology, physics 20200721 5


<h4>Purpose</h4>The COVID-19 outbreak is affecting people worldwide. Many infected patients have respiratory involvement that may progress to acute respiratory distress syndrome. This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiation therapy in patients with COVID-19 pneumonia.<h4>Methods and materials</h4>In this clinical trial, conducted in Iran, we enrolled patients with COVID-19 who were older than 60 years and hospitalized to receive supplementary oxygen f  ...[more]

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