Ontology highlight
ABSTRACT:
SUBMITTER: Ren S
PROVIDER: S-EPMC7374011 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ren Shuxun S Chang Sunny S Tran Alex A Mandelli Arianna A Wang Yibin Y Wang Jessica J JJ
Journal of visualized experiments : JoVE 20191003 152
Isoproterenol (ISO), is a non-selective beta-adrenergic agonist, that is used widely to induce cardiac injury in mice. While the acute model mimics stress-induced cardiomyopathy, the chronic model, administered through an osmotic pump, mimics advanced heart failure in humans. The purpose of the described protocol is to create the chronic ISO-induced heart failure model in mice using an implanted mini-pump. This protocol has been used to induce heart failure in 100+ strains of inbred mice. Techni ...[more]