Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib.
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ABSTRACT:
SUBMITTER: Buckley AM
PROVIDER: S-EPMC7374542 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib.
Buckley Amy M AM Dunne Margaret R MR Morrissey Maria E ME Kennedy Susan A SA Nolan Aoife A Davern Maria M Foley Emma K EK Clarke Niamh N Lysaght Joanne J Ravi Narayanasamy N O'Toole Dermot D MacCarthy Finbar F Reynolds John V JV Kennedy Breandán N BN O'Sullivan Jacintha J
Scientific reports 20200721 1
Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however the 5-year survival rates remain at < 20%. To improve treatment outcomes it is critical to further investigate OAC tumour biology, metabolic phenotype and their metabolic adaptation to different oxygen tensions. In this study, by using human ex-vivo explants we demonstrated ...[more]
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