Unknown

Dataset Information

0

Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the T2-weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic- co-glycolic acid) (PLGA) nanoparticles using Pickering emulsification present 18-fold higher relaxivity than encapsulated SPIONs and 1.5-fold higher relaxivity than free SPIONs. In contrast, the SPIONs immobilized on 10 ?m diameter PLGA particles exhibit a minor increase in MR relaxivity. This interesting finding will significantly impact current efforts to synthesize and assemble advanced MR contrast agents.

SUBMITTER: Lee MK 

PROVIDER: S-EPMC7374926 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal.

Lee Min Kyung MK   Clay Nicholas E NE   Ko Eunkyung E   Smith Cartney E CE   Chen Lin L   Cho Nicholas N   Sung Hak-Joon HJ   DiPietro Luisa L   Lee Jonghwi J   Kong Hyunjoon H  

Langmuir : the ACS journal of surfaces and colloids 20181207 50

Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the T<sub>2</sub>-weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic- co-glycolic acid) (PLGA) nanopa  ...[more]

Similar Datasets

Unknown Superparamagnetic iron oxide nanoparticle micelles stabilized by recombinant oleosin for targeted magnetic resonance imaging.
| S-EPMC4746475 | biostudies-literature
Unknown Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide.
| S-EPMC6199858 | biostudies-literature
Unknown Washing effect on superparamagnetic iron oxide nanoparticles.
| S-EPMC4838932 | biostudies-literature
Unknown Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.
| S-EPMC5357746 | biostudies-literature
Unknown Mn(ii) chelate-coated superparamagnetic iron oxide nanocrystals as high-efficiency magnetic resonance imaging contrast agents.
| S-EPMC9416939 | biostudies-literature
Unknown Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles.
| S-EPMC5766481 | biostudies-literature
Unknown Heparin-Superparamagnetic Iron Oxide Nanoparticles for Theranostic Applications.
| S-EPMC9611043 | biostudies-literature
Unknown High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging.
| S-EPMC4330038 | biostudies-literature
Unknown High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles.
| S-EPMC7367688 | biostudies-literature
Unknown Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy.
| S-EPMC5997278 | biostudies-literature