Ontology highlight
ABSTRACT:
SUBMITTER: Lin CT
PROVIDER: S-EPMC7375814 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Lin Chih-Tung CT Lecca Daniela D Yang Ling-Yu LY Luo Weiming W Scerba Michael T MT Tweedie David D Huang Pen-Sen PS Jung Yoo-Jin YJ Kim Dong Seok DS Yang Chih-Hao CH Hoffer Barry J BJ Wang Jia-Yi JY Greig Nigel H NH
eLife 20200626
Traumatic brain injury (TBI) causes mortality and disability worldwide. It can initiate acute cell death followed by secondary injury induced by microglial activation, oxidative stress, inflammation and autophagy in brain tissue, resulting in cognitive and behavioral deficits. We evaluated a new pomalidomide (Pom) analog, 3,6'-dithioPom (DP), and Pom as immunomodulatory agents to mitigate TBI-induced cell death, neuroinflammation, astrogliosis and behavioral impairments in rats challenged with c ...[more]