Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC7376279 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Li Wen W Midgley Adam C AC Bai Yanli Y Zhu Meifeng M Chang Hong H Zhu Wenying W Wang Lina L Wang Yuhao Y Wang Hongjun H Kong Deling D
Biomaterials 20190912
Improved strategies for the treatment of tendon defects are required to successfully restore mechanical function and strength to the damaged tissue. This remains a scientific and clinical challenge, given the tendon's limited innate regenerative capacity. Here, we present an engineering solution that stimulates the host cell's remodeling abilities. We combined precision-designed templates with subcutaneous implantation to generate decellularized autologous extracellular matrix (aECM) scaffolds t ...[more]