Ontology highlight
ABSTRACT:
SUBMITTER: Douglas C
PROVIDER: S-EPMC7377362 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Douglas Charlotte C Turner James M A JMA
PLoS genetics 20200723 7
There is currently a requirement for single-sex litters for many applications, including agriculture, pest control, and reducing animal culling in line with the 3Rs principles: Reduction, Replacement, and Refinement. The advent of CRISPR/Cas9 genome editing presents a new opportunity with which to potentially generate all-female or all-male litters. We review some of the historical nongenetic strategies employed to generate single-sex litters and investigate how genetic and genome editing techni ...[more]