Dataset Information

Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19.

ABSTRACT: BACKGROUND:Obesity was recently identified as a major risk factor for worse COVID-19 severity, especially among the young. The reason why its impact seems to be less pronounced in the elderly may be due to the concomitant presence of other comorbidities. However, all reports only focus on BMI, an indirect marker of body fat. AIM:To explore the impact on COVID-19 severity of abdominal fat as a marker of body composition easily collected in patients undergoing a chest CT scan. METHODS:Patients included in this retrospective study were consecutively enrolled among those admitted to an Emergency Department in Rome, Italy, who tested positive for SARS-Cov-2 and underwent a chest CT scan in March 2020. Data were extracted from electronic medical records. RESULTS:150 patients were included (64.7% male, mean age 64?±?16?years). Visceral fat (VAT) was significantly higher in patients requiring intensive care (p?=?0.032), together with age (p?=?0.009), inflammation markers CRP and LDH (p?

SUBMITTER: Watanabe M

PROVIDER: S-EPMC7377788 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19.

Watanabe Mikiko M Caruso Damiano D Tuccinardi Dario D Risi Renata R Zerunian Marta M Polici Michela M Pucciarelli Francesco F Tarallo Mariarita M Strigari Lidia L Manfrini Silvia S Mariani Stefania S Basciani Sabrina S Lubrano Carla C Laghi Andrea A Gnessi Lucio L

Metabolism: clinical and experimental 20200723

<h4>Background</h4>Obesity was recently identified as a major risk factor for worse COVID-19 severity, especially among the young. The reason why its impact seems to be less pronounced in the elderly may be due to the concomitant presence of other comorbidities. However, all reports only focus on BMI, an indirect marker of body fat.<h4>Aim</h4>To explore the impact on COVID-19 severity of abdominal fat as a marker of body composition easily collected in patients undergoing a chest CT scan.<h4>Me ...[more]

PMID: 32712222

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Project description:PURPOSE:The coronavirus disease 2019 (COVID-19) poses major challenges to health-care systems worldwide. This pandemic demonstrates the importance of timely access to intensive care and, therefore, this study aims to explore the accessibility of intensive care beds in 14 European countries and its impact on the COVID-19 case fatality ratio (CFR). METHODS:We examined access to intensive care beds by deriving (1) a regional ratio of intensive care beds to 100,000 population capita (accessibility index, AI) and (2) the distance to the closest intensive care unit. The cross-sectional analysis was performed at a 5-by-5 km spatial resolution and results were summarized nationally for 14 European countries. The relationship between AI and CFR was analyzed at the regional level. RESULTS:We found national-level differences in the levels of access to intensive care beds. The AI was highest in Germany (AI?=?35.3), followed by Estonia (AI?=?33.5) and Austria (AI?=?26.4), and lowest in Sweden (AI?=?5) and Denmark (AI?=?6.4). The average travel distance to the closest hospital was highest in Croatia (25.3 min by car) and lowest in Luxembourg (9.1 min). Subnational results illustrate that capacity was associated with population density and national-level inventories. The correlation analysis revealed a negative correlation of ICU accessibility and COVID-19 CFR (r?=?- 0.57; p?<?0.001). CONCLUSION:Geographical access to intensive care beds varies significantly across European countries and low ICU accessibility was associated with a higher proportion of COVID-19 deaths to cases (CFR). Important differences in access are due to the sizes of national resource inventories and the distribution of health-care facilities relative to the human population. Our findings provide a resource for officials planning public health responses beyond the current COVID-19 pandemic, such as identifying potential locations suitable for temporary facilities or establishing logistical plans for moving severely ill patients to facilities with available beds.

Dataset Information

Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19.

Publications

Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19.

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