Ontology highlight
ABSTRACT:
SUBMITTER: Spitale FM
PROVIDER: S-EPMC7377853 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Spitale Federica Maria FM Vicario Nunzio N Rosa Michelino Di MD Tibullo Daniele D Vecchio Michele M Gulino Rosario R Parenti Rosalba R
Aging 20200624 13
Amyotrophic lateral sclerosis (ALS) is one of the most common motoneuronal disease, characterized by motoneuronal loss and progressive paralysis. Despite research efforts, ALS remains a fatal disease, with a survival of 2-5 years after disease onset. Numerous gene mutations have been correlated with both sporadic (sALS) and familiar forms of the disease, but the pathophysiological mechanisms of ALS onset and progression are still largely uncertain. However, a common profile is emerging in ALS pa ...[more]