Ontology highlight
ABSTRACT:
SUBMITTER: Liang R
PROVIDER: S-EPMC7379129 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liang Rui R Yao Yuanfei Y Wang Guangyu G Yue Er E Yang Guangchao G Qi Xiuying X Wang Yang Y Zhao Ling L Zheng Tongsen T Zhang Yanqiao Y Wenge Wang Edward E
Frontiers in oncology 20200716
Quinacrine has been identified as a potent DR5-inducing agent that sensitizes cancer cells to TRAIL-induced apoptosis. In the current study, we found that quinacrine increased DR5 mRNA levels significantly in ovarian cancer cell lines regardless of p53 status. Further study showed the half-life of DR5 in quinacrine-treated cells was significantly prolonged, indicating that DR5 protein degradation was inhibited by quinacrine. We tested if the combination of TRAIL and quinacrine could be effective ...[more]