Toward a rational design of combination therapy in cancer.
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ABSTRACT: By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse - free survival.
SUBMITTER: Doucey MA
PROVIDER: S-EPMC4589060 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
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