Ontology highlight
ABSTRACT:
SUBMITTER: Lu W
PROVIDER: S-EPMC7380183 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lu Wen W Ai Heng H Xue Fusheng F Luan Yifei Y Zhang Bin B
The Journal of biological chemistry 20200604 29
Homeostatic scaling of the synapse, such as synaptic down-scaling, has been proposed to offset deleterious effects induced by sustained synaptic strength enhancement. Proper function and subcellular distribution of Src homology 2 domain-containing nonreceptor protein tyrosine phosphatase (SHP2) are required for synaptic plasticity. However, the role of SHP2 in synaptic down-scaling remains largely unknown. Here, using biochemical assays and cell-imaging techniques, we found that synaptic SHP2 le ...[more]